The Pronk Pops Show 1312, August 27, 2019, Breaking News — Story 1: Islamic Republic of Iran Will Not Meet With United States Until Sanctions Are Lifted — Trump Waiting for A Pretext To Attack — Iranian Will Give Him One — Iranian People Must Overthrow Their Totalitarian Theocracy Regime — Videos — Story 2: Johnson and Johnson Ordered To Pay $572 Million in Case Involving Marketing of Opioids to Doctors — Videos — Story 3: 19 States Sue Federal Government Over Longer Detention in Family Residential Centers (FRCs) Until Processed Under New Rule

Posted on August 28, 2019. Filed under: 2020 Republican Candidates, Addiction, Addiction, American History, Banking System, Blogroll, Breaking News, Budgetary Policy, Communications, Congress, Constitutional Law, Corruption, Countries, Crime, Culture, Defense Spending, Donald J. Trump, Donald J. Trump, Donald J. Trump, Donald Trump, Drugs, Economics, Education, Elections, First Amendment, Fiscal Policy, Foreign Policy, Free Trade, Freedom of Speech, Government, Government Dependency, Government Spending, Health, History, House of Representatives, Human, Human Behavior, Illegal Drugs, Illegal Immigration, Immigration, Impeachment, Independence, Labor Economics, Law, Legal Drugs, Legal Immigration, Life, Lying, Media, Medicare, Mental Illness, Military Spending, Monetary Policy, National Interest, National Security Agency, News, People, Philosophy, Photos, Politics, Polls, Privacy, Progressives, Public Corruption, Radio, Raymond Thomas Pronk, Regulation, Resources, Scandals, Second Amendment, Security, Senate, Spying, Surveillance and Spying On American People, Surveillance/Spying, Tax Policy, Taxation, Taxes, Trade Policy, Unemployment, United States Constitution, United States of America, Videos, Violence, Wealth, Welfare Spending, Wisdom | Tags: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |

 

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Story 1: Islamic Republic of Iran Will Not Meet With United States Until Sanctions Are Lifted — Trump Waiting for A Pretext To Attack — Iranian Will Give Him One — Iranian People Must Overthrow Their Totalitarian Theocracy Regime — Both Iran and North Korea Must Denuclearize of Face Sanction Forever — Videos

 

Iran will meet with US if sanctions are lifted

Donald Trump calls Iran ‘number one nation of terror’

[9AM] America’s Newsroom 8/27/19 | FOX News Today August 27, 2019

Trump: Iran cannot have a nuclear weapon

Trump confronts nuclear threats from Iran and North Korea

President Donald Trump On The Iran Nuclear Deal | CNBC

Sanctions aren’t enough to end Iran’s nuclear program: Walid Phares

President Trump Open To Meeting With Iran, Says China Wants To Make A Trade Deal | NBC Nightly News

Iran FM Zarif: “If the US stops bothering the rest of the world, everything will be fine”

Iran’s Zarif grabs #MSC2019 spotlight, slams Trump and Israel (Munich Security Conference)

Iran’s Zarif thrashes Trump, “US driven by pathological obsession” (Munich Security Conference 2019)

The Middle East’s cold war, explained

Inside Iran

Iran: Why are people protesting?

Protests in Iran enter sixth day

Published on Jan 2, 2018

 

Iran’s Rouhani Says No Talks With Trump Until Sanctions Are Lifted

CreditCreditIranian Presidency, via Agence France-Presse — Getty Images

President Hassan Rouhani of Iran said on Tuesday that he would not sit down for a meeting with President Trump until Washington had lifted all of its economic sanctions against Iran.

His comment came a day after President Emmanuel Macron of France said he would try to arrange a meeting between Mr. Trump and Mr. Rouhani in the next few weeks to ease the strained relationship between the United States and Iran.

That relationship has worsened since Mr. Trump abandoned the Iranian nuclear agreement last year and imposed crippling sanctions on Iran’s economy.

Mr. Macron said at a news conference on Monday at the conclusion of the Group of 7 meeting in France that he had spoken with his Iranian counterpart to determine whether a meeting was possible.

Opioid Overdose Crisis

Revised January 2019

Every day, more than 130 people in the United States die after overdosing on opioids.1 The misuse of and addiction to opioids—including prescription pain relieversheroin, and synthetic opioids such as fentanyl—is a serious national crisis that affects public health as well as social and economic welfare. The Centers for Disease Control and Prevention estimates that the total “economic burden” of prescription opioid misuse alone in the United States is $78.5 billion a year, including the costs of healthcare, lost productivity, addiction treatment, and criminal justice involvement.2

How did this happen?

In the late 1990s, pharmaceutical companies reassured the medical community that patients would not become addicted to prescription opioid pain relievers, and healthcare providers began to prescribe them at greater rates. This subsequently led to widespread diversion and misuse of these medications before it became clear that these medications could indeed be highly addictive.3,4 Opioid overdose rates began to increase. In 2017, more than 47,000 Americans died as a result of an opioid overdose, including prescription opioids, heroin, and illicitly manufactured fentanyl, a powerful synthetic opioid.1 That same year, an estimated 1.7 million people in the United States suffered from substance use disorders related to prescription opioid pain relievers, and 652,000 suffered from a heroin use disorder (not mutually exclusive).5

What do we know about the opioid crisis?

  • Roughly 21 to 29 percent of patients prescribed opioids for chronic pain misuse them.6
  • Between 8 and 12 percent develop an opioid use disorder.6
  • An estimated 4 to 6 percent who misuse prescription opioids transition to heroin.79
  • About 80 percent of people who use heroin first misused prescription opioids.7
  • Opioid overdoses increased 30 percent from July 2016 through September 2017 in 52 areas in 45 states.10
  • The Midwestern region saw opioid overdoses increase 70 percent from July 2016 through September 2017.10
  • Opioid overdoses in large cities increase by 54 percent in 16 states.10
The graph shows that the Northeast had the highest rate of suspected opioid overdose in Q3 of 2017. Rates in the Midwest have increased largely between Q2 and Q3 of 2017.Quarterly rate of suspected opioid overdose, by US region
Source: Centers for Disease Control and Prevention.10

This issue has become a public health crisis with devastating consequences including increases in opioid misuse and related overdoses, as well as the rising incidence of neonatal abstinence syndrome due to opioid use and misuse during pregnancy. The increase in injection drug use has also contributed to the spread of infectious diseases including HIV and hepatitis C. As seen throughout the history of medicine, science can be an important part of the solution in resolving such a public health crisis.

What are HHS and NIH doing about it?

In response to the opioid crisis, the U.S. Department of Health and Human Services (HHS) is focusing its efforts on five major priorities:

  1. improving access to treatment and recovery services
  2. promoting use of overdose-reversing drugs
  3. strengthening our understanding of the epidemic through better public health surveillance
  4. providing support for cutting-edge research on pain and addiction
  5. advancing better practices for pain management

The National Institutes of Health (NIH), a component of HHS, is the nation’s leading medical research agency helping solve the opioid crisis via discovering new and better ways to prevent opioid misuse, treat opioid use disorders, and manage pain. In the summer of 2017, NIH met with pharmaceutical companies and academic research centers to discuss:

  1. safe, effective, non-addictive strategies to manage chronic pain
  2. new, innovative medications and technologies to treat opioid use disorders
  3. improved overdose prevention and reversal interventions to save lives and support recovery

In April 2018 at the National Rx Drug Abuse and Heroin Summit, NIH Director Francis S. Collins, M.D., Ph.D., announced the launch of the HEAL (Helping to End Addiction Long-term) Initiative, an aggressive, trans-agency effort to speed scientific solutions to stem the national opioid public health crisis.

Related Resources

https://www.drugabuse.gov/drugs-abuse/opioids/opioid-overdose-crisis

Types of Pain

Acute pain can last a moment; rarely does it become chronic pain. Chronic pain persists for long periods. It is resistant to most medical treatments and cause severe problems.

  1. Pain ClassificationsEven though the experience of pain varies from one person to the next, it is possible to categorize the different types of pain.
  2. Chronic PainLearn about how chronic pain occurs, and why chronic pain sometimes lingers.
  3. Nerve PainWhen nerve fibers get damaged, the result can be chronic pain. Read about the very common causes of neuropathic pain, like diabetes.
  4. Psychogenic PainDepression, anxiety, and other emotional problems can cause pain — or make existing pain worse.
  5. Musculoskeletal PainMusculoskeletal pain is pain that affects the muscles, ligaments and tendons, and bones. Learn about the causes, symptoms, and treatments.
  6. Chronic Muscle PainUse your muscles incorrectly, too much, too little — and you’ve got muscle pain. Learn the subtle differences of muscle injuries and pain.
  7. Abdominal PainLearn common causes of abdominal pain and when to contact your doctor.
  8. Joint PainSee the causes of joint pain and how to treat it with both home remedies and prescribed medication.
  9. Central Pain SyndromeA stroke, multiple sclerosis, or spinal cord injuries can result in chronic pain and burning syndromes from damage to brain regions. Read this brief overview.
  10. Complex Regional Pain SyndromeIt’s a baffling, intensely painful disorder that can develop from a seemingly minor injury, yet is believed to result from high levels of nerve impulses being sent to the affected disorder. Learn more about this disorder.
  11. Diabetes-Related Nerve Pain (Neuropathy)If you have diabetes, nerve damage can be a serious complication. This nerve complication can cause severe burning pain especially at night. Learn more about diabetic neuropathy.
  12. Shingles Pain (Postherpetic Neuralgia)Shingles is a painful condition that arises from varicella-zoster, the same virus that causes chickenpox. Learn more about the symptoms and risk factors.
  13. Trigeminal NeuralgiaIt’s considered one of the most painful conditions in medicine. The face pain it causes can be treated. Learn more about what causes trigeminal neuralgia and treatments for face pain caused by it. 

https://www.webmd.com/pain-management/guide/pain-management-overview-facts

 

The opioid crisis just keeps getting worse, in part because new types of drugs keep finding their way onto the streetsFentanyl, heroin’s synthetic cousin, is among the worst offenders.It’s deadly because it’s so much stronger than heroin, as shown by the photograph above, which was taken at the New Hampshire State Police Forensic Laboratory. On the left is a lethal dose of heroin, equivalent to about 30 milligrams; on the right is a 3-milligram dose of fentanyl, enough to kill an average-sized adult male.Fentanyl, according to the Centers for Disease Control and Prevention, is up to 100 times more potent than morphine and many times that of heroin.Drugs users generally don’t know when their heroin is laced with fentanyl, so when they inject their usual quantity of heroin, they can inadvertently take a deadly dose of the substance. In addition, while dealers try to include fentanyl to improve potency, their measuring equipment usually isn’t fine-tuned enough to ensure they stay below the levels that could cause users to overdose. Plus, the fentanyl sold on the street is almost always made in a clandestine lab; it is less pure than the pharmaceutical version and thus its effect on the body can be more unpredictable.Heroin and fentanyl look identical, and with drugs purchased on the street, “you don’t know what you’re taking,” Tim Pifer, the director of the New Hampshire State Police Forensic Laboratory, told STAT in an interview. “You’re injecting yourself with a loaded gun.”

New Hampshire, like the rest of New England, has been particularly hard hit by the opioid epidemic. The state saw a total of 439 drug overdoses in 2015; most were related to opioids, and about 70 percent of these opioid-related deaths involved fentanyl. The state has seen 200 deadly opioid overdoses this year so far, said Pifer.

Fentanyl was originally used as an anesthetic. Then doctors realized how effective it was at relieving pain in small quantities and started using it for that purpose. In the hands of trained professionals — and with laboratory-grade equipment — fentanyl actually has a pretty wide therapeutic index, or range within which the drug is both effective and safe.

The difference in strength between heroin and fentanyl arises from differences in their chemical structures. The chemicals in both bind to the mu opioid receptor in the brain. But fentanyl gets there faster than morphine — the almost-instantaneous byproduct when the body breaks down heroin — because it more easily passes through the fat that is plentiful in the brain. Fentanyl also hugs the receptor so tightly that a tiny amount is enough to start the molecular chain of events that instigates opioids’ effects on the body.

“In a fentanyl overdose, you may not be able to totally revive the person with the Narcan dose you have,” said Scott Lukas, director of the Behavioral Psychopharmacology Research Laboratory at McLean Hospital in Belmont, Mass. “Naloxone easily knocks morphine off of the receptor, but does that less so to fentanyl.”

Why fentanyl is deadlier than heroin, in a single photo

 

 

Carfentanil

PubChem CID: 62156
Structure:
Carfentanil_small.png
Carfentanil_3D_Structure.png
Molecular Formula: C24H30N2O3
Chemical Names:

CARFENTANIL

Carfentanyl

Carfentanila

Carfentanilum

Wildnil

Molecular Weight: 394.5 g/mol
Dates:
  • Modify:2019-08-24
  • Create:2005-03-28

Carfentanil is a monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of methyl 4-anilino-1-(2-phenylethyl)piperidine-4-carboxylate with propanoic acid. It has a role as a mu-opioid receptor agonist, an opioid analgesic and a tranquilizing drug. It is a member of piperidines, a methyl ester, a tertiary amino compound and a tertiary carboxamide.

from ChEBI

Carfentanil or carfentanyl (Wildnil) is an analogue of the popular synthetic opioid analgesic fentanyl, and is one of the most potent opioids known (also the most potent opioid used commercially). Carfentanil was first synthesized in 1974 by a team of chemists at Janssen Pharmaceutica which included Paul Janssen. It has a quantitative potency approximately 10,000 times that of morphine and 100 times that of fentanyl, with activity in humans starting at about 1 microgram. It is marketed under the trade name Wildnil as a general anaesthetic agent for large animals. Carfentanil is intended for large-animal use only as its extreme potency makes it inappropriate for use in humans. Currently sufentanil, approximately 10–20 times less potent (500 to 1000 times the efficacy of morphine per weight) than carfentanil, is the maximum strength fentanyl analog for use in humans.

https://pubchem.ncbi.nlm.nih.gov/compound/carfentanil

Story 3: 19 States Sue Federal Government Over Longer Detention in Family Residential Centers (FRCs) Until Processed Under New Rule

States plan legal action against Trump’s new immigration plan

Child migrants to be held in detention longer under new rule

News Wrap: 19 states sue over extended migrant detention limits

Trump Administration To Allow Longer Detention Of Migrant Families

Trump administration ends “loophole” immigration rule that could keep kids in detention for longer

Flores Settlement

19 States and D.C. Sue to Block Trump’s Termination of Flores Agreement

AUG 27, 2019

H8 migrant children families detention immigration trump flores agreement lawsuits

Nineteen states and the District of Columbia sued Monday to block the Trump administration’s recent move rolling back limits on detaining child migrants and migrant families. The 1997 Flores agreement caps the jailing of migrant children and families to 20 days before they must be released or transferred to a licensed care facility. California Attorney General Xavier Becerra said, “This new Trump rule callously puts at risk the safety and well-being of children. No child deserves to be left in conditions inappropriate and harmful for their age. We’re taking the Trump Administration to court to protect children from the irreparable harm caused by unlawful and unnecessary detention.”

 

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Listen To Pronk Pops Podcast or Download Shows 58-61

Listen To Pronk Pops Podcast or Download Shows 55-57

Listen To Pronk Pops Podcast or Download Shows 52-54

Listen To Pronk Pops Podcast or Download Shows 49-51

Listen To Pronk Pops Podcast or Download Shows 45-48

Listen To Pronk Pops Podcast or Download Shows 41-44

Listen To Pronk Pops Podcast or Download Shows 38-40

Listen To Pronk Pops Podcast or Download Shows 34-37

Listen To Pronk Pops Podcast or Download Shows 30-33

Listen To Pronk Pops Podcast or Download Shows 27-29

Listen To Pronk Pops Podcast or Download Shows 17-26

Listen To Pronk Pops Podcast or Download Shows 16-22

Listen To Pronk Pops Podcast or Download Shows 10-15

Listen To Pronk Pops Podcast or Download Shows 1-9

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